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Forced mutations doom HIV

Fifteen years ago, MIT professor John Essigmann and colleagues from the University of Washington had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably, they could force it to weaken and eventually die out — a strategy that our immune system uses against many viruses.

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No Link Between Efavirenz and Neurocognitive Impairment in Italian Study

The widely used antiretroviral drug efavirenz was not linked with neurocognitive impairment in a study reported this week at AIDS 2014. Efavirenz (Sustiva, also part of the popular Atripla combo pill) has been associated with a variety of neuropsychiatric symptoms ranging from vivid dreams to depression, but whether the drug contributes to neurocognitive impairment (NCI) has been debated.

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PrEP Works Despite Missed Doses, Although Daily Use Is Advised

No one who took Truvada PrEP at least four times per week acquired HIV in the iPrEx Open Label Extension (iPrEx OLE) demonstration project, according to data presented today at the AIDS 2014 conference in Melbourne. These new data support PrEP as a valuable HIV prevention option even when adherence may be less than 100%.

“Adherence has to be good, not great,” said iPrEx protocol chair Robert Grant, MD, MPH, of the Gladstone Institutes, the University of California at San Francisco, and San Francisco AIDS Foundation, in his late-breaker presentation of the study results.

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